Probio Femina – 5 Lactobacillus Cultures (20 Billion CFU), Inulin, Cranberries, and Zinc in One Daily Capsule

Probio Femina is a comprehensive dietary supplement tailored to the female microbiome. In a single capsule, it combines five Lactobacillus cultures totaling 20 billion CFU (L. rhamnosus, L. reuteri, L. gasseri, L. acidophilus, and L. crispatus), 250 mg of prebiotic inulin, 100 mg of concentrated cranberry extract (50:1), and 5 mg of zinc. The entire composition is enhanced with BioPerine®, a standardized source of piperine from black pepper. The formulation is gluten-free, lactose-free, and GMO-free and is also suitable for vegetarians.

Female Microbiome and Lactobacilli

The vaginal microbiome is unique in that, in healthy women of reproductive age, lactobacilli significantly predominate in it, unlike in other parts of the body.¹ Extensive analysis of the vaginal microbiome has classified it into several types, with Lactobacillus crispatus being the species most associated with a healthy and stable vaginal microbiome and often referred to as its biomarker.¹ This strain is not as common in standard supplements as L. rhamnosus or L. reuteri. However, you will find it in Probio Femina as part of a carefully selected quintet of probiotic cultures.²

Inulin as a Prebiotic Fiber

The cultures are supplemented with 250 mg of inulin, a soluble fiber from chicory, which is classified as a prebiotic, meaning substances selectively utilized by microorganisms in the body.³ These are not digested in the small intestine and are fermented by the gut microbiota. The combination of probiotic cultures and prebiotic fiber in one product is referred to as a synbiotic.⁴

Cranberry as a Source of Proanthocyanidins

The large cranberry (Vaccinium macrocarpon) is a rich source of type A proanthocyanidins (PAC). These are plant compounds from the flavonoid group, specifically polyphenols, which are among the most widespread plant substances in nutrition.⁵ Cranberries differ from most other fruits in that they contain predominantly type A PAC, whereas other fruits tend to contain type B.⁶ Each capsule contains 100 mg of concentrated extract in a 50:1 ratio.

Zinc for Immunity and Reproduction

An integral part of the composition is zinc (5 mg, 50% NRV). It contributes to the normal function of the immune system, to normal fertility and reproduction, and to the protection of cells from oxidative stress.

Who It Is Suitable For

• You want the less common L. crispatus: In addition to common lactobacilli, you will also receive Lactobacillus crispatus – the species most associated with a healthy and stable vaginal microbiome, which is usually not found in standard supplements.
• You want a 2-in-1 solution in a single capsule: Probiotic cultures and prebiotic inulin are combined, so you do not need to combine two separate products.
• You will appreciate the zinc: 5 mg of zinc (50% NRV) contributes to the normal function of the immune system, fertility and reproduction, and the protection of cells from oxidative stress.
• You want simplicity: Just one capsule a day, no mixing or measuring required. Unlike liquid probiotics, they do not require refrigeration and are easy to take with you.

How to Take Probio Femina

Take 1 capsule daily with any meal and drink with water. Cultures pass through the digestive tract more effectively with food. Store in a dry place at room temperature; refrigeration is not required. One package contains 60 servings.

Probio Femina and Its Benefits

• 5 Lactobacillus cultures totaling 20 billion CFU in one capsule
• Synbiotic combination of probiotics and prebiotics (inulin)
• 100 mg of 50:1 cranberry extract, a source of type A proanthocyanidins
• Zinc (50% NRV) for immunity, fertility, and protection of cells from oxidative stress
• Vegetarian, gluten-free, lactose-free, and GMO-free
• No refrigeration required – practical for home and travel

Sources and Scientific References

1. Ravel J, et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci U S A. 2011;108(Suppl 1):4680–4687.
2. Hill C, et al. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506–514.
3. Gibson GR, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017;14(8):491–502.
4. Swanson KS, et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat Rev Gastroenterol Hepatol. 2020;17(11):687–701.
5. Rauf A, et al. Proanthocyanidins: A comprehensive review. Biomed Pharmacother. 2019;116:108999.
6. Carpenter JL, et al. Variation in proanthocyanidin content and composition among commonly grown North American cranberry cultivars (Vaccinium macrocarpon). J Sci Food Agric. 2014;94(13):2738–2745.

Table of Active Ingredients

*Nutrient Reference Value.

Warnings

Dietary supplement. Do not exceed the recommended daily dose. Dietary supplements must not be used as a substitute for a varied and balanced diet and a healthy lifestyle. The product is not intended for children, pregnant, or breastfeeding women. Keep out of reach of small children. Store in a dry place away from direct sunlight at room temperature.

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